abstract：:A prospective study was performed in patients treated with cisplatin to evaluate the occurrence and degree of central, peripheral and autonomic neuropathy and to determine the most accurate method to study this neuropathy. Twelve patients were examined before, during and after treatment. Evaluation included neurologic...

journal_title：Journal of neuro-oncology

authors： Boogerd W,ten Bokkel Huinink WW,Dalesio O,Hoppenbrouwers WJ,van der Sande JJ

更新日期：1990-12-01 00:00:00

abstract：:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour thr...

journal_title：Journal of neuro-oncology

authors： Chan KW,Fryer CJ,Steinbok P

更新日期：1990-10-01 00:00:00

abstract：:A phase II trial of Homoharringtonine (HHT) was performed in 15 patients with recurrent or progressive malignant glioma. The drug was administered at a initial dose of 4 mg/m2/day by continuous 5 day intravenous infusion (3 mg/m2/day x 5 days for heavily pretreated patients). Courses were repeated every 3-4 weeks upon...

journal_title：Journal of neuro-oncology

authors： Feun LG,Savaraj N,Landy H,Levin H,Lampidis T

更新日期：1990-10-01 00:00:00

abstract：:A positron emission tomography study using [18F]-fluorodeoxyglucose was undertaken to identify and quantitate whether diaschisis occurred in cerebral cortex, basal ganglia, or thalamus, as well as in cerebellar cortex and dentate nuclei in patients with malignant glioma. The relationship between diaschisis in these ce...

journal_title：Journal of neuro-oncology

authors： Rozental JM,Levine RL,Nickles RJ,Dobkin JA,Hanson JM

更新日期：1990-04-01 00:00:00

abstract：:Transfection of primary cultures of human cells with origin of replication deficient SV40 DNA has been carried out by others to generate in vitro models of malignant transformation in vivo. The present work describes progressive alterations in karyotype and phenotype in one such transfected (neuroglial) cell line (SVG...

journal_title：Journal of neuro-oncology

authors： Davey P,Rauth AM,Mason L,Addy L

更新日期：1990-02-01 00:00:00

abstract：:Glucocorticoids, such as betamethasone, are often used to prevent possible acute reactions during radiation therapy of intracranial tumors (for example gliomas). The effect of the glucocorticoids is probably due to vascular changes decreasing the development of edemas. The radiosensitivity of two studied cell-lines of...

journal_title：Journal of neuro-oncology

authors： Benediktsson G,Blomquist E,Carlsson J

更新日期：1990-02-01 00:00:00

abstract：:One hundred-twenty seven human brain tumors were examined by an immunoperoxidase technique for the expression of collagen Type IV, a major constituent of basement membrane. The parenchymal components were negative for the marker protein in all tumors except for neurilemmomas which were positively stained. In every cas...

journal_title：Journal of neuro-oncology

authors： Ogawa K,Oguchi M,Nakashima Y,Yamabe H

更新日期：1989-11-01 00:00:00

abstract：:The toxicity of IL-2 and/or C. Parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of IL-2, different solvents for the IL-2, and different doses and routes of administration of C. Parvum. Two injections was found signific...

journal_title：Journal of neuro-oncology

authors： Sutton RC 3rd,Kennedy J,Duncan J,Conley FK

更新日期：1989-09-01 00:00:00

abstract：:We have developed an in vitro assay for Natural Killer (NK) cell cytolysis of and binding to substrate attached human glioma and fetal brain cells. The monolayer cells were labeled with [51Cr] and the effectors were directly sedimented onto these substrate attached target cells. Using this method we screened several g...

journal_title：Journal of neuro-oncology

authors： Kazimer RM,Whisler RL,Stephens RE,Pearl DK,Yates AJ

更新日期：1989-07-01 00:00:00

abstract：:Levels of rhodamine 123 (Rh-123), a new antineoplastic drug, were measured using high performance liquid chromatography in normal brain, malignant glioma and brain adjacent to tumor after a single intravenous injection of drug into rats with intracerebral tumors. Consistently higher levels of Rh-123 were seen in tumor...

journal_title：Journal of neuro-oncology

authors： Powers SK,Ellington K

更新日期：1988-12-01 00:00:00

abstract：:Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while ...

journal_title：Journal of neuro-oncology

authors： Paggi MG,Carapella CM,Fanciulli M,Del Carlo C,Giorno S,Zupi G,Silvestrini B,Caputo A,Floridi A

更新日期：1988-11-01 00:00:00

abstract：:In the human glioblastoma cell line, T-MG1, plasminogen activator activity (PA-activity) was demonstrated by using the chromogenic substrate S-2251. Using monoclonal antibodies against human urokinase type PA (u-PA) and human tissue type PA (t-PA), only u-PA activity was found in T-MG1 cell extracts. The u-PA activity...

journal_title：Journal of neuro-oncology

authors： Helseth E,Dalen A,Unsgaard G,Vik R

更新日期：1988-11-01 00:00:00

abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

journal_title：Journal of neuro-oncology

authors： Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

更新日期：1987-01-01 00:00:00

abstract：:Invasion of the meninges is a relatively common complication of head and neck rhabdomyosarcoma (RMS), while RMS arising primarily within the brain or meninges is rare. We report the case of an 11-year old child with a primary "primitive" frontal lobe tumor, subsequent leptomeningeal spread and fatal intratumoral hemor...

journal_title：Journal of neuro-oncology

authors： Dropcho EJ,Allen JC

更新日期：1987-01-01 00:00:00

abstract：:An anti-epithelial membrane antigen monoclonal (Clone E29) was used as part of a panel of antisera in the investigation of primary CNS and metastatic tumours. In contrast to others, definite and often strongly positive cross-reactivity has been demonstrated on glial cells. The material consisted of fourteen astrocytom...

journal_title：Journal of neuro-oncology

authors： Hitchcock E,Morris CS

更新日期：1987-01-01 00:00:00

abstract：:Pituitary tumors were experimentally induced in female Wistar rats by repeated injections of estradiol dipropionate. The hypothalamus and pituitary tumors were studied simultaneously by fluorescence histochemistry and immunohistochemistry. The pituitary gland became larger with a concomitant increase of serum prolacti...

journal_title：Journal of neuro-oncology

authors： Fujimoto M,Yoshino E,Hirakawa K,Chihara K,Ibata Y

更新日期：1987-01-01 00:00:00

abstract：:Twenty-eight patients with malignant brain tumors (16 with primary brain tumors and 12 with brain metastases) progressing after cranial irradiation with or without chemotherapy received varying doses of intracarotid VP-16. Courses of therapy were repeated every 4 weeks along with computerized axial tomography scan and...

journal_title：Journal of neuro-oncology

authors： Feun LG,Lee YY,Yung WK,Savaraj N,Wallace S

更新日期：1987-01-01 00:00:00

abstract：:A 65 year old woman presented with a recurrent locally advanced esthesioneuroblastoma. She had earlier been treated with radiation followed by surgery. The recurrence was located in earlier radiated tissues with intracranial infiltration. She underwent treatment with combined intra-arterial chemotherapy (BCNU) i.a., v...

journal_title：Journal of neuro-oncology

authors： Watne K,Hager B

更新日期：1987-01-01 00:00:00

abstract：:Anguidine pretreatment was previously shown to potentiate cis-platinum in Chinese hamster ovary cells by 100-fold, probably by enhancing cellular cis-platinum uptake. Since both cis-platinum and anguidine have been reported to have clinical efficacy in human brain tumors, the present study was initiated to investigate...

journal_title：Journal of neuro-oncology

authors： Hromas RA,Yung WK

更新日期：1986-01-01 00:00:00

abstract：:The records of 14 patients with a tumour in the pineal or supra-sellar region seen at The Norwegian Radium Hospital, Oslo between 1973-1980 have been studied retrospectively. The problems with a widely accepted classification are discussed, as well as the choice of treatment (surgery versus radiation) and the indicati...

journal_title：Journal of neuro-oncology

authors： Watne K

更新日期：1986-01-01 00:00:00

abstract：:A case of a functioning invasive pituitary oncocytoma in a 50-year-old man is reported. The serum prolactin was increased and immunocytochemical staining was positive for prolactin. In addition to numerous mitochondria within the neoplastic cells, structurally abnormal mitochondria with crystalline inclusions were als...

journal_title：Journal of neuro-oncology

authors： Chowdhury C,Roy S,Gupta N,Kochupillai N,Banerji AK

更新日期：1986-01-01 00:00:00

abstract：:Unexpected early epidural spinal metastasis in a case of osteosarcoma occurred in a patient receiving treatment with cis-diamminedichloroplatinum-II (cisplatin). The initial neurologic symptomatology manifested as paresthesias in the feet which developed 2 months after initiation of treatment (cumulative dose of cispl...

journal_title：Journal of neuro-oncology

authors： Shimizu H,Jaffe N,Kleinerman E

更新日期：1986-01-01 00:00:00

abstract：:Alkaline phosphatase (ALPase) and Mg2+-activated ATPase (Mg2+-ATPase) activities were demonstrated in human brain tumors by light and electron microscopy. Four cases of glioma, i.e., two cases of astrocytoma, grade II, and two cases of glioblastoma, were used as materials. At the light microscopic level, Mg2+-ATPase a...

journal_title：Journal of neuro-oncology

authors： Maeda T,Nishiyama F,Ogashiwa M,Takeuchi K,Hirano H

更新日期：1985-01-01 00:00:00

abstract：:Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a p...

journal_title：Journal of neuro-oncology

authors： Pedersen AG,Paulson OB,Gyldensted C

更新日期：1985-01-01 00:00:00

abstract：:The cerebrospinal fluid (CSF) pharmacokinetics of cytosine arabinoside (Ara-C) was determined in 8 patients with metastatic cancer in the central nervous system. High dose (3 gm/M2) one-hour intravenous infusions of Ara-C were given with serial CSF sampling obtained from indwelling Ommaya reservoirs. CSF was analyzed ...

journal_title：Journal of neuro-oncology

authors： Lopez JA,Nassif E,Vannicola P,Krikorian JG,Agarwal RP

更新日期：1985-01-01 00:00:00

abstract：:We describe two patients with fatal vascular malformations of the thalamus whom we thought had gliomas. They had progressive neurological impairment with subacute onset as adults. Computed tomography showed lesions of increased density with slight post-contrast enhancement; cerebral angiography was normal. Without bio...

journal_title：Journal of neuro-oncology

authors： Norcross K,Ciric IS,Mikhael MA,Vick NA

更新日期：1985-01-01 00:00:00

abstract：:The soft agar technique for culturing human clonogenic tumor cells has been usefully applied for predicting individual clinical responses to chemotherapy, for screening of new antineoplastic drugs, and in basic biological research. The counting of colonies formed by clonogenic cells is, however, a rather time consumin...

journal_title：Journal of neuro-oncology

authors： Unsgaard G,Larsen B,Dalen A,Vik R,Ringkjøb R

更新日期：1985-01-01 00:00:00

abstract：:Thirty-six infants and children with brain stem glioma diagnosed between 1967 and 1980 were reviewed. Posterior fossa craniotomy was performed in 25, with biopsy or partial resection in 18, cyst aspiration in 2, and exploration alone in 5. The 19 surgical specimens obtained revealed neoplastic cells in 15 but only gli...

journal_title：Journal of neuro-oncology

authors： Tomita T,McLone DG,Naidich TP

更新日期：1984-01-01 00:00:00

abstract：:Radiolabelled Baker's Antifolate (BAF) was administered to 6 patients undergoing surgical resection of intracerebral tumors. Levels of radioactivity in resected tumor and edematous brain adjacent to tumor were generally higher than levels in concurrent plasma samples and were generally comparable to levels in temporal...

journal_title：Journal of neuro-oncology

authors： Stewart DJ,Leavens M,Lu K,Wang YM,Benjamin RS,Ho DH,Yap HY,Loo TL

更新日期：1984-01-01 00:00:00

abstract：:Increasing interest has developed in the use of the photodynamic agent, Hematoporphyrin derivative (HpD) for photoradiation therapy (PRT) as adjunctive therapy of malignant glial tumors of the brain. HpD, injected systemically, is preferentially taken up and retained by neoplastic tissue. Early studies of such uptake ...

journal_title：Journal of neuro-oncology

authors： Little FM,Gomer CJ,Hyman S,Apuzzo ML

更新日期：1984-01-01 00:00:00

abstract：:Two patients with metastasis from lung carcinoma of the midbrain are presented. The computerized tomographic (CT) findings mimicked a primary pineal tumor, but autopsy confirmed a metastatic nodule in the midbrain in both cases. The rational approach to posterior third ventricular tumors seen on CT in adulthood is dis...

journal_title：Journal of neuro-oncology

authors： Tomita T,Wetzel N

更新日期：1984-01-01 00:00:00

abstract：:Thirty-one patients with metastatic brain tumors that either failed to respond or recurred after conventional therapy were treated by intra-arterial infusion of 100 mg/m2 of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) into either a carotid or vertebral artery. Five patients (three with lung cancer, one with breast can...

journal_title：Journal of neuro-oncology

authors： Cascino TL,Byrne TN,Deck MD,Posner JB

更新日期：1983-01-01 00:00:00

abstract：:A pilot study was performed combining cis-diamminedichloroplatinum (CDDP) and radiation therapy to treat patients with high-grade astrocytomas. CDDP at a dose of 40 mg/m2/week intravenously was given during the course of cranial irradiation. Following irradiation, CDDP was given every three weeks on a schedule of 35-4...

journal_title：Journal of neuro-oncology

authors： Feun LG,Stewart DJ,Maor M,Leavens M,Savaraj N,Burgess MA,Yung WK,Benjamin RS

更新日期：1983-01-01 00:00:00

abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

journal_title：Journal of neuro-oncology

authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

更新日期：1983-01-01 00:00:00